Brandelli was born in London. His first work was Squire - launched in 1992, it was the first project of its type to draw and encompass many different types of design aesthetics, using art, fashion and design in a concept space in Mayfair which epitomised the beginnings of 'Cool Britannia'. The gallery displayed design collections within the same space as classic ‘pop art’ pieces from artists such as Allen Jones and Bridget Riley. Early collaborators, clients and admirers of Squire were Alexander McQueen (who wore Squire designs to his first historic Givenchy interview), Massive Attack, Helmut Lang and most of the iconoclasts of design, music and style scenes. Nick Knight and Peter Saville (Photographer and Art Director respectively) were initial collaborators.
Squire questioned the boundaries between design,fashion and art, pioneering a more open and broad spectrum of how designers were perceived to be able to work within other creative disciplines and mediums. Specialising in tailoring, Brandelli used traditional Savile Row craft together with relevant modern design principles.
In 2002, Kilgour approached Brandelli to become Creative Director. Brandelli set the brief to create a modern hybrid menswear brand combining the craft and heritage of Savile Row with all aspects of modern current design. The project was critically and commercially very successful with Brandelli receiving many diverse plaudits and awards including British GQ’s most Stylish man and being voted Menswear designer of the year in 2005 by the British Fashion Council. In 2008 Kilgour changed ownership, and Brandelli resigned as Creative & Design Director.
In 2009 Brandelli established his own studio near Milan. The studio is focusing on artistic work, his first sculpture solo show ‘Permanence 2010 - Travertine marble stone & gold’ opened on June 25th 2010 at RCM Galerie in Paris. Brandelli has also shown work at Casey Kaplan gallery in New York and is now a regular contributor to the contemporary art scene.